Raporo y'Urubanza rw'Ubuvuzi bw'Igihe Kirekire ku Kanseri za GPC3 CAR T (CT011)

CT011 ni ubwoko bwa GPC3 CAR T-cells bukoreshwa mu kuvura kanseri y'umwijima (HCC). CT011 yahawe uburenganzira bwa IND na NMPA mu 2019 bwo kuvura abarwayi bafite kanseri ikomeye ya GPC3-positive, ikaba ari yo ndunduro ya mbere y’ubuvuzi bwa IND mu Bushinwa ku barwayi ba kanseri ikomeye ya CAR T.

Ku ya 18 Kanama 2022, CARsgen Therapeutics itangaza ko raporo y'urubanza, yiswe "Long Term Term Complete Response of Advanced Hepatocellular Carcinoma to Glypican-3 Specific Chimeric Antigen Receptor T-Cells plus Sorafenib, A case report", yasohotse mu kinyamakuru Frontiers in Immunology.

Uru rubanza rwagaragaje umurwayi w’umugabo w’imyaka 60 wo muri Aziya urwaye virusi ya hepatite B (HBV) yakozwe muri Gicurasi 2018. Muri Kanama 2018, nyuma yo kubagwa yongeye kurwara kanseri y’umwijima no kwangirika kw’ibihaha, hanyuma ahabwa imiti igabanya ubukana bw’umwijima (TACE) kugira ngo avure ibisebe by’umwijima no kuvura indwara z’ibihaha. Nyuma y’amezi abiri, yakomeje kujya mu igeragezwa ry’ubuvuzi. Nyuma yo kwiyandikisha, umurwayi yakorewe leukapheresis kugira ngo akore selile za CAR-GPC3 T. Nyuma y’iminsi irindwi leukapheresis ibaye, umurwayi yatangiye guhabwa 400 mg ya sorafenib kabiri ku munsi. Umurwayi yahawe 4 cycles za CAR-GPC3 T cells (CT011) kandi buri cycle yagabanyijwemo kabiri. Mbere ya buri cycle yo kuvurwa na CT011, hakozwe lymphodepletion. 4 × 10 zose hamwe.⁹Uturemangingo twa CAR-GPC3 T twashyizwemo.

Uburyo bwo kuvura bwa CT011 hamwe na sorafenib bwari bwihanganiwe neza. Uyu murwayi yabonye ibisubizo by'igice (PR) kuva mu kwezi kwa 3, maze agera kuri CR mu kwezi kwa 12 nyuma y'icyiciro cya mbere cyo guterwa CT011. Iki kibyimba nticyakomeje kwiyongera mu gihe kirenga amezi 36, kandi cyakomeje kuba CR mu gihe kirenga amezi 24 nyuma yo guterwa bwa mbere.

Uko tubizi, iki ni cyo kibazo cya mbere cyagaragaye ku barwayi ba CR nyuma yo kuvura uturemangingo twa CAR T hamwe n’imiti ibuza tyrosine kinase. Ibyavuye mu bushakashatsi byagaragaje ko kuvura uturemangingo twa GPC3 CAR T na Sorafenib bishobora kuba uburyo bushya bwiza ku barwayi ba GPC3+ bakuze ba HCC.

Kuri ubu, hari andi magerageza menshi ya CAR-T mu Bushinwa, kandi barimo gushaka abarwayi. Kugira ngo ubone inama ku miti mishya n'ikoranabuhanga, ushobora kuvugana n'Ishami Mpuzamahanga ry'Ibitaro bya Oncology bya Beijing Region South.

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