Ku ya 21 Werurwe 2025, Immunofoco yatangaje ko ubuvuzi bwayo bwa EpCAM-targeting autologous CAR-T cell therapy, IMC001, bwemerewe n'Ikigo gishinzwe Isuzuma ry'Imiti (CDE) munsi y'Ikigo cy'Igihugu gishinzwe Ibikoresho by'Ubuvuzi (NMPA) mu Bushinwa ku nshuro ya kabiri cyo gukoresha imiti mishya (IND), gifite inomero yo kwemererwa CXSL2400901. Ubu buryo bwa IND bugamije kuvura kanseri ikomeye ya EpCAM. Mbere yaho, IMC001 yari yarabonye uburenganzira bwa IND mu Bushinwa no muri Leta Zunze Ubumwe za Amerika muri Gashyantare 2024 bwo kuvura kanseri y'igifu ya EpCAM-positive.
Molekile y’uturemangingo tw’imbere mu mubiri (EpCAM) igaragara cyane ku tunyangingo dutandukanye tw’uturemangingo dukomoka ku tunyangingo, harimo kanseri yo mu gifu, kanseri y’inkondo y’umura, kanseri ya pancreas, kanseri y’intanga ngore, kanseri y’ibihaha, kanseri y’igifu, na kanseri y’ibere. Ibinyuranye n’ibyo, igaragara hasi mu tunyangingo dusanzwe. Nubwo hari imbogamizi nko kugorana kw’ibidukikije bikomeye bya tumori no gutandukana kw’ibinyangingo, IMC001 yagaragaje umutekano mwiza n’ubushobozi bw’ibanze mu igeragezwa rya mbere ry’indwara za kanseri yo mu gifu, bitewe n’uburyo itoranyamo ubwoko bwihariye bw’ibinyangingo n’imiterere yayo mishya. Iki kimenyetso cy’inyongera kigamije kurushaho gusuzuma ubushobozi bwayo bwo kuvura.
Mu biganiro byatanzwe ku rubuga rwa ASCO na CSCO byo mu 2024, amakuru y’ubushakashatsi bwa IIT ku buvuzi bwa IMC001 yagaragaje ko mu barwayi 10 bapimwe barwaye kanseri y’igifu, igipimo cyo kurwanya indwara cyari 90%, aho umurwayi umwe mu itsinda ry’abahawe dose nkeya ari 33.3% n’ababiri mu itsinda ry’abahawe dose yo hagati ari 40% babonye igisubizo cy’igice (PR). Igipimo rusange cyo kubaho (OS) mu itsinda ry’abahawe dose yo hagati cyarenze ibyumweru 55. Umurwayi umwe mu itsinda ry’abahawe dose yo hagati yabonye PR yemejwe mu cyumweru cya 24, bituma abagwa mu nda mu cyumweru cya 27, kandi umurwayi yari amaze amezi arenga 22 akiriho kugeza ku itariki ntarengwa.
Gukuraho iyi IND y'inyongera ni intambwe ikomeye mu kwagura uburyo bwo gushakisha indwara bwa IMC001 kuva ku tumori two mu gifu kugera ku bwoko bwa kanseri ikomeye yo mu ruhu, harimo kanseri y'ibihaha y'uturemangingo duto (SCLC), kanseri y'ibere y'impinja eshatu (TNBC), n'izindi kanseri.
Kugeza ubu, haracyari igeragezwa ryinshi ry’ikoranabuhanga rishya rirwanya kanseri mu Bushinwa rishaka abarwayi. Inama ku miti mishya n’ikoranabuhanga, ushobora kuvugana n’Ishami Mpuzamahanga ry’Ibitaro bya Oncology bya Beijing mu Karere k’Amajyepfo.
Nimero ya Terefone: 4008803716
Email：myimmnet@163.com
Igihe cyo kohereza: Mata-03-2025