CDE y'Ubushinwa yemereye uburyo bwo kuvura indwara ya kanseri (Breakthrough Therapy) kuba GFH375 kuri KRAS G12D-Mutant NSCLC

Ku ya 13 Gashyantare 2026, Ikigo gishinzwe Isuzuma ry'Imiti (CDE) cy'Ikigo cy'Igihugu gishinzwe Ibikoresho by'Ubuvuzi mu Bushinwa cyatangaje ko ibinini bya GFH375 byashyizwe mu cyiciro cya Breakthrough Therapy Designation cyo kuvura abarwayi ba kanseri y'ibihaha ya KRAS G12D-mutant non-small cell cancer (NSCLC) bahawe nibura ubuvuzi bumwe mbere.

Gusesa Amategeko y'Intego "Idakoreshwa mu Kunywa Inzoga"

Impinduka za KRAS zafatwaga n'abaganga nk'intego "idashobora gutinda". Ariko, uko ubushakashatsi bwa siyansi bugenda butera imbere, iki kibazo kirimo kugerwaho buhoro buhoro. KRAS G12D ni imwe mu moko akunze kugaragara cyane ya mpinduka za KRAS, ikunze kugaragara muri adenocarcinoma ya pancreas ductal (PDAC), kanseri y'ibihaha itari iy'uturemangingo duto (NSCLC), na kanseri y'inkondo y'umura.

Amakuru ashyigikira ubuvuzi: GFH375 igaragaza imikorere ikomeye yo kurwanya ikibyimba

Amakuru y’ubuvuzi yavuye mu igerageza rya GFH375 mu cyiciro cya mbere cy’igerageza ryakozwe kuri GFH375 ku barwayi bafite kanseri y’ubwoko bwa KRAS G12D-mutant solid tumors, yatanzwe mu nama ngarukamwaka ya 2025 y’Umuryango w’Abanyamerika w’Ubuvuzi bw’Ubwonko (ASCO), yatanze ibisubizo bishimishije. Ayo makuru yagaragaje ko GFH375 ishobora gukoreshwa mu kanwa neza kandi ko ikoreshwa neza mu gukumira kanseri. Kugeza ku itariki ntarengwa y’amakuru, abarwayi 62 bafite kanseri y’ubwoko bwa KRAS G12D-mutant solid tumors bari baravuwe bari mu igerageza rya GFH375 mu buryo bumwe.

Amatsinda y'abantu bapimwe ku gipimo cy'intego: Imikorere myiza cyane

Mu barwayi 49 bahabwaga dose ya 400mg cyangwa 600mg ku munsi mu kanwa, amakuru y’imikorere y’iyi dose yari atangaje cyane:

  Igipimo rusange cy’ingaruka ku ntego (ORR): Mu barwayi 43 bapimwe, ORR yageze kuri 42%, naho Igipimo cyo Kurwanya Indwara (DCR) cyari hejuru cyane kigera kuri 91%.

   Abarwayi ba Pancreatic Ductal Adenocarcinoma (PDAC): Mu barwayi 23 ba PDAC bapimwe, ORR yari 52%, naho DCR igera ku 100%.

   Abarwayi ba kanseri y'ibihaha itari nto (NSCLC): Mu barwayi 12 ba NSCLC bapimwe, ORR yari 42%, naho DCR yari 83%.

Amatsinda yose y'ingero: Igikorwa cyagutse kandi cy'ingenzi

Mu barwayi 52 bakoze nibura isuzuma rimwe nyuma yo kuvurwa, ORR mu byiciro byose by’imiti yari 38%, DCR ikaba 90%. Ikigaragara ni uko abarwayi 38 bagabanutseho ibisebe by’imiti, naho abarwayi 20 bakira igice cy’imiti. Iyi mibare y’ibanze igaragaza ko GFH375 igaragaza imikorere ikomeye mu gukumira ibibyimba ku barwayi bafite ibibyimba bikomeye nka PDAC na NSCLC, harimo n’abamaze gutera imbere nyuma yo kuvurwa inshuro nyinshi.

Guhangana n’intambwe nk’izo z’ubuvuzi zigezweho, guhitamo ikigo cy’ubuvuzi gishobora gutanga uburyo bwo kuvura buhanitse na serivisi zirambuye ni ingenzi cyane. Ishami Mpuzamahanga ryita ku Bitaro bya Oncology bya Beijing mu Karere k’Amajyepfo ryiyemeje gutanga serivisi zigezweho zo gusuzuma no kuvura kanseri ku barwayi bo mu gihugu no mu mahanga. Dukomeza kumenya amakuru agezweho mu bushakashatsi mpuzamahanga ku bijyanye na kanseri kandi twiyemeje kugeza ku barwayi bakeneye ubufasha ku buryo bwihuse.

Ibyiza byacu birimo:

Ibisubizo by’Ubuvuzi Bigezweho: Tugendana n’amahame mpuzamahanga, twibanda ku buryo bugezweho bwo kuvura burimo GFH375, dutanga amahirwe yo kuvura abarwayi bafite impinduka za KRAS G12D.

Itsinda ry’impuguke mu by’ubuvuzi bw’indwara za kanseri: Duhuza impuguke zikomeye mu by’ubuvuzi bw’indwara za kanseri mu gihugu zifatanya mu nama z’ubuvuzi bw’indwara za kanseri kugira ngo dutegure gahunda zihariye kandi zinoze zo kuvura umurwayi wese.

Amahame Mpuzamahanga ya Serivisi: Kuva ku nama, gahunda yo kubonana n'abaganga, serivisi zo guhindura ubuvuzi kugeza ku gikorwa cyose cyo kuvurwa, dutanga itumanaho risobanutse neza kandi twitaye ku barwayi mpuzamahanga n'imiryango yabo, tubafasha kubona ubunararibonye bwiza kandi buhumuriza mu buvuzi.

Ubufasha bwuzuye ku barwayi: Duharanira kuba indashyikirwa mu kuvura gusa, ahubwo tunaharanira imibereho myiza y’abarwayi mu mutwe no mu mibereho myiza, dutanga ubufasha n’ubuvuzi.

Twandikire ubu kugira ngo umenye icyizere gishya cyo kuvurwa

Niba wowe cyangwa umwe mu bagize umuryango wawe mwaranduye kanseri y’ibihaha itari iy’uturemangingo duto twa KRAS G12D cyangwa izindi kanseri zikomeye kandi zikaba zitarakira neza uburyo bwo kuvura busanzwe, nyamuneka hamagara Ishami Mpuzamahanga ryita ku Bitaro bya Oncology bya Beijing mu Karere k’Amajyepfo. Itsinda ryacu ry’inzobere rizaguha amakuru agezweho y’ubuvuzi n’inama zijyanye no gusuzuma indwara n’ubuvuzi.

Twandikire ukoresheje uburyo bukurikira:

Terefone: 400-880-3716

WeChat: 17801183037

Email: 100085_010@163.com 或 myimmnet@163.com

Ntureke intera cyangwa inzitizi z'ururimi biba inzitizi mu gushaka ubuvuzi buhanitse. Ishami Mpuzamahanga ryita ku Bitaro bya Oncology bya Beijing mu Karere k'Amajyepfo riri hano kugira ngo rifatanye nawe mu kurwanya kanseri.