Ku ya 24 Mata 2025, GenFleet Therapeutics yatangaje ko Ikigo gishinzwe Ibiribwa n'Imiti muri Amerika (FDA) cyemeje ikoreshwa ry'umuti mushya (IND) wa GFH375/VS-7375, umuti ubuza KRAS G12D (ON/OFF) mu kanwa, mu igerageza ry'ubuvuzi rivura abarwayi ba kanseri ikomeye bafite imihindagurikire ya KRAS G12D. Ubu bushakashatsi buteganijwe gutangizwa n'umufatanyabikorwa wa GenFleet witwa Verastem Oncology muri Amerika ahagana hagati mu 2025. Ubushakashatsi bwa mbere bwakozwe ku bantu kuri GFH375 bwatangijwe na GenFleet mu Bushinwa bwageze mu cyiciro cya kabiri kandi amakuru y'ibanze ku mikorere n'umutekano by'ubu bushakashatsi yatoranyijwe mu buryo bwihuse mu nama ngarukamwaka y'Umuryango w'Abanyamerika w'Ubuvuzi bw'Imiti (ASCO) iteganyijwe mu 2025.
Poroteyine za RAS, mu buryo bwa GTP-bound cyangwa GDP-bound idakora, ni binary molekile switches zigenzura uburyo selile zikora mu nzira z’ibimenyetso zirimo RAS-RAF-MEK-ERK na PI3K/AKT/mTOR. Utunyangingo dutatu twa RAS dushyiraho isoforms za poroteyine, ari two Kirsten Ras (KRAS), Harvey Ras (HRAS) na Neuroblastoma Ras (NRAS), kandi KRAS ni yo oncogene ikunze guhinduka cyane mu bantu. Mu mpinduka za KRAS, G12D, G12V, na G12C ni zo alleles eshatu za mbere zihinduka cyane. Impinduka za KRAS G12D zikunze kuboneka muri adenocarcinoma ya pancreas, kanseri y’inkondo y’umura, na adenocarcinoma y’ibihaha.
Ijanisha rinini ry'abarwayi bafite impinduka za KRAS G12D baboneka badafite amateka yo kunywa itabi kandi badafite igisubizo kibi ku miti igabanya ubukana bwa PD-1. Imiti igabanya ubukana bwa G12D ifite icyizere cyo kugirira akamaro ibyiciro byinshi by'abarwayi ba PDAC bakomoka kuri KRAS kuko impinduka za KRAS G12D ari zo zikunze kugaragara cyane ku barwayi ba PDAC (hafi 40%) bivugwa ko bafite igipimo cyo kubaho imyaka 5 kiri munsi ya 10%.
GFH375 ni umuti ugabanya ubukana bw’uturemangingo duto twa KRAS G12D (ON/OFF) mu kanwa, ukomeye kandi utoranya cyane, wagenewe kwibasira ihererekanya rya GTP/GDP, bityo ugahagarika uburyo bwo kunyura mu nzira zo hasi no kugabanya ku buryo bufatika ikwirakwira ry’uturemangingo twa kanseri. Inyigo zakozwe mbere y’isuzuma ryerekanye ko ingano y’uturemangingo iterwa n’umuti iterwa n’umuti mu buryo busanzwe, mu buryo busanzwe bufite impinduka za KRAS G12D; GFH375 yanagaragaje ko hari ingaruka nke mu guhitamo neza no gusuzuma ingamba z’umutekano.
Kugeza ubu, haracyari igeragezwa ryinshi ry’ikoranabuhanga rishya rirwanya kanseri mu Bushinwa rishaka abarwayi. Inama ku miti mishya n’ikoranabuhanga, ushobora kuvugana n’Ishami Mpuzamahanga ry’Ibitaro bya Oncology bya Beijing mu Karere k’Amajyepfo.
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Igihe cyo kohereza: 25 Mata 2025