Lynparza ivanze na Abiraterone na Prednisolone yemejwe mu Bushinwa ku barwayi ba mCRPC bahinduwe na BRCA

Ku ya 31 Nyakanga, AstraZeneca na Merck & Co. batangaje ku bufatanye ko umuti wabo wa Lynparza ugabanya PARP, hamwe na Abiraterone na prednisolone, wemejwe mu Bushinwa mu kuvura abarwayi bakuru barwaye kanseri ya prostate idashobora kwangirika (mCRPC) bafite imiterere ya germline cyangwa somatic BRCA mutations (gBRCAm cyangwa sBRCAm).

Kugeza ubu, haracyari igeragezwa ryinshi ry’ikoranabuhanga rishya rirwanya kanseri mu Bushinwa rishaka abarwayi. Inama ku miti mishya n’ikoranabuhanga, ushobora kuvugana n’Ishami Mpuzamahanga ry’Ibitaro bya Oncology bya Beijing mu Karere k’Amajyepfo.

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Lynparza (olaparib) ni umuti wa mbere wo mu rwego rwa PARP ubuza ADN kwangirika (DDR) mu turemangingo/ibibyimba bifite ikibazo cya HRR, nko guhinduka kwa BRCA1 na/cyangwa BRCA2. Kubuza PARP hamwe na Lynparza gutuma PARP ifata DNA imwe, igahagarika imashini zikora, igasenyuka ndetse ikanatuma ADN ebyiri zicikamo ibice ndetse n’urupfu rw’uturemangingo twa kanseri.

Uku kwemezwa kwashingiye ahanini ku byavuye mu isesengura ry’amatsinda mato yavuye mu itsinda ry’abantu ku isi no mu Bushinwa mu igerageza rya PROpel Phase III. PROpel ni igerageza ry’ubuvuzi ryakozwe mu buryo butunguranye, ridafite ubwiza bubiri, rigizwe n’abantu benshi mu cyiciro cya gatatu, risuzuma imikorere, umutekano, n’uburyo Lynparza yihanganirwa hamwe na Abiraterone na prednisolone ugereranije na placebo hamwe na Abiraterone na prednisolone ku barwayi b’abagabo bafite mCRPC batarigeze bahabwa imiti ya chimiotherapie cyangwa imiti mishya ikoreshwa mu misemburo (NHA) ku rwego rwa mCRPC.

Amakuru yavuye mu itsinda ry’abarwayi ku isi yose bafite impinduka za BRCA yagaragaje ko Lynparza hamwe na Abiraterone byagaragaje iterambere rikomeye mu kuvura indwara zidafite ingaruka ku mikorere ya radiography (rPFS) ugereranije na Abiraterone monotherapy. Isesengura ry’amatsinda mato y’abarwayi bafite impinduka za BRCA mu itsinda ry’abarwayi ku isi ryagaragaje ko Lynparza yahujwe na Abiraterone byagabanyije ibyago byo kwiyongera kw’indwara cyangwa urupfu ku kigero cya 76% n’ibyago byo gupfa ku kigero cya 70%. Igipimo cya rPFS n’igipimo cya rPFS mu itsinda rya Lynparza hamwe na Abiraterone byari bitaragerwaho, mu gihe igipimo cya rPFS n’igipimo cya rPFS mu itsinda rya Abiraterone monotherapy byari amezi 8 n’amezi 23, uko bikurikirana.

Kugeza ubu, haracyari igeragezwa ryinshi ry’ikoranabuhanga rishya rirwanya kanseri mu Bushinwa rishaka abarwayi. Inama ku miti mishya n’ikoranabuhanga, ushobora kuvugana n’Ishami Mpuzamahanga ry’Ibitaro bya Oncology bya Beijing mu Karere k’Amajyepfo.

Nimero ya Terefone: 4008803716

Indangamuntu ya WeChat: 17801183037

Email：myimmnet@163.com