Amakuru y'ibanze ku buvuzi kuri Allogeneic BCMA CAR-T CT0596, agaragaza umutekano mwiza n'imikorere myiza

Ku ya 12 Gicurasi 2025, CARsgen yatangaje amakuru y’ibanze ku buvuzi bwa CT0596, CAR-T ikoreshwa mu buryo bwa allogeneic BCMA yakozwe hakoreshejwe urubuga rwa THANK-u Plus™. CT0596 ubu irimo gusuzumwa mu bushakashatsi bwa mbere ku ndwara ya myeloma nyinshi yasubiwemo/igwa (R/R MM) cyangwa leukemia y’uturemangingo twa plasma yasubiwemo/igwamo (R/R PCL) kugira ngo harebwe umutekano wayo, n’ubushobozi bwayo bw’ibanze.

Ku ya 6 Gicurasi 2025, abarwayi 8 bafite R/R MM bari barahawe nibura imirongo itatu y’ubuvuzi mbere banditswe kandi baterwa CT0596 nyuma yo gutakaza lymphodepletion hamwe na regimen ya FC (fludarabine 22.5-30 mg/m² na cyclophosphamide 350-500 mg/m²). Ibyavuye mu bushakashatsi kugeza ku mezi ane y’ikurikirana birimo:

Nta burozi bugabanya urugero rw'umuti (DLTs), indwara yo kugabanya ubukana bw'uturemangingo (CRS) yo mu cyiciro cya 3 (Grade 3), indwara y'uburozi bw'imitsi iterwa n'umubiri (ICANS), cyangwa indwara ya graft-versus-host (GVHD) byagaragaye. Uyu muti wagaragaje umutekano mwiza, nta barwayi bahagaritse kuvurwa bitewe n'ingaruka mbi.

1) Mu barwayi 5 barangije isuzuma rya mbere ry’imikorere myiza mu cyumweru cya 4, abarwayi 3 (60%) babonye igisubizo cyuzuye/igisubizo cyuzuye (sCR/CR), naho abarwayi 4 (80%) babonye indwara ntoya isigara (MRD) - negativity mu musokoro w’amagufwa. 2) Amakuru y’imikorere y’abarwayi 2 ku munsi wa 14 yagaragaje ko ibisebe bipimwa byagabanutseho ≥92% na ≥65%, uko bikurikirana. 3) Umurwayi 1 yari ataragera ku gihe cyo gusuzuma imikorere y’imikorere cyagenwe na protocole.

Abarwayi bose ba SCR/CR bakomeje gusubizwa, harimo n'umurwayi wa mbere warangije gukurikirana mu mezi ane.

Hashingiwe ku makuru y’ibanze yerekeye umutekano n’imikorere myiza, CT0596 yagaragaje ko ishobora kwihanganira no gutera imbaraga ibimenyetso by’imikorere myiza ku barwayi ba R/R MM ku rugero rwose rwagenwe, hamwe n’ubwiyongere bwa CAR-T. Ibi byavumbuwe bisaba ubushakashatsi burambuye atari muri R/R MM gusa, ahubwo no mu zindi ndwara za kanseri zo mu maraso n’indwara ziterwa n’uturemangingo twa plasma dukora ku buryo butunguranye.

Kugeza ubu, haracyari igeragezwa ryinshi ry’ikoranabuhanga rishya rirwanya kanseri mu Bushinwa rishaka abarwayi. Inama ku miti mishya n’ikoranabuhanga, ushobora kuvugana n’Ishami Mpuzamahanga ry’Ibitaro bya Oncology bya Beijing mu Karere k’Amajyepfo.

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