Ku ya 16 Mutarama 2025, IMPACT yatangaje ko imiti ya Senaparib Capsules (派舒宁®）yahawe uburenganzira bwo kwamamaza mu Bushinwa n’Ikigo cy’Igihugu gishinzwe Ibikoresho by’Ubuvuzi (NMPA) nk’uburyo bwo kuvura abarwayi bakuru bafite kanseri y’intanga ngabo, imiyoboro y’amaraso cyangwa kanseri y’imbere mu nda (FIGO Stage III na IV) bafite kanseri y’intanga ngabo, y’imiyoboro y’amaraso cyangwa kanseri y’imbere mu nda itera indwara (yuzuye cyangwa igice) nyuma yo kurangiza imiti ya platine ikoresha platine.
Senaparib, yavumbuwe kandi igakorwa na IMPACT, ni umuti ukomeye kandi udasanzwe wo gukumira PARP 1/2. Imiterere yayo yihariye ya molekile iwuha imikorere myinshi muri vitro no mu mubiri, guhitamo neza intego hamwe n'umwanya munini w'umutekano. Kwemezwa gushingiye ku bushakashatsi bwa FLAMES. Ubu bushakashatsi ni ubushakashatsi bwakorewe mu buryo butaziguye, butabona kabiri, bugenzurwa na placebo, bukorerwa mu nzego nyinshi, icyiciro cya gatatu kugira ngo harebwe akamaro n'umutekano wa Senaparib nk'umuti umwe wo kuvura abarwayi ba kanseri y'intanga ngore iteye imbere barangije imiti ya kanseri yo mu cyiciro cya mbere kandi bakaba barabonye igisubizo cyuzuye (CR) cyangwa igisubizo cy'igice (PR). Ibisubizo by'ubushakashatsi bwa FLAMES byagaragaje ko Senaparib yagaragaje iterambere rigaragara muri PFS isanzwe ugereranije na placebo (PFS itaragera ku mezi 13.6, HR 0.43, P < 0.0001), hatitawe ku miterere ya BRCA. Senaparib yagaragaje umutekano wihanganirwa, nta kibazo kigaragara cy'umutekano. [1] Ibisubizo byagaragaje kandi ko abantu barwaye HRD n'abadafite HRD bungukira mu buvuzi bwo kubungabunga Senaparib, bigaragaza ubushobozi bwa Senaparib mu buvuzi rusange. Ibisubizo by'ubu bushakashatsi bizashyigikira cyane Senaparib nk'urwego rw'ubuvuzi bw'ibanze ku barwayi barwaye kanseri y'intanga ngore nshya.
Ibisubizo by’ingenzi by’ubushakashatsi byabanje kugaragazwa nk’ibiganiro byatanzwe mu kanwa bitinze muri ESMO mu 2023, binagaragazwa muri CSCO 2024. Ku ya 15 Gicurasi 2024, ikinyamakuru cy’ubuvuzi kizwi ku rwego mpuzamahanga Nature Medicine nacyo cyasohoye ibyavuye mu bushakashatsi cyitwa “Senaparib nk’ubuvuzi bwa mbere bwo kubungabunga kanseri y’intanga ngore: igerageza ryakozwe ku buryo butaziguye mu cyiciro cya 3.”
Kanseri y'intanga ngore ni imwe mu ndwara zica cyane ku bagore. Dukurikije imibare ya GLOBOCAN 2020, ku isi hose kanseri y'intanga ngore igera ku 310.000, naho impfu zigera ku 210.000. Dukurikije imibare iheruka yashyizwe ahagaragara n'Ikigo cy'Igihugu gishinzwe Kanseri mu 2024, hari abantu 61.100 bashya barwaye kanseri y'intanga ngore n'abapfuye 32.600 mu Bushinwa mu 2022, ibi bikaba ari byo bibyimba bikomeye mu bagore. Bitewe n'ibimenyetso bya mbere bya kanseri y'intanga ngore, hafi 80% by'abarwayi baba bari mu cyiciro cyo hejuru igihe basuzumwa, kandi igipimo cyo kubaho imyaka 5 ni 41.8% gusa. Nubwo kanseri y'intanga ngore ishobora gukemuka nyuma yo gutangira gukoresha imiti ya platine, abarwayi benshi bahura n'ikibazo cyo kongera kugaruka, kandi haracyari ikibazo gikomeye cyo kuvurwa mu barwayi ba kanseri y'intanga ngore.
Kugeza ubu, haracyari igeragezwa ryinshi ry’ikoranabuhanga rishya rirwanya kanseri mu Bushinwa rishaka abarwayi. Inama ku miti mishya n’ikoranabuhanga, ushobora kuvugana n’Ishami Mpuzamahanga ry’Ibitaro bya Oncology bya Beijing mu Karere k’Amajyepfo.
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Igihe cyo kohereza: Gashyantare 18-2025