Ku ya 10 Gashyantare 2025, CARsgen Therapeutics yatangaje ko umuntu wa mbere wavuwe hakoreshejwe uburyo bwa BCMA CAR-T bukoresha allogeneic bwakorewe kuri platform ya THANK-u Plus™, yageze ku gisubizo gikomeye (sCR) n'ububi buke bw'indwara zisigara (MRD) mu isuzuma ry'umunsi wa 28. Urwego rwa THANK-u Plus™ rwakorewe mu kigo, ni ikoranabuhanga rishya rya CAR-T rigamije gukemura ibibazo byo kugerwaho n'abantu mu buvuzi bwa CAR-T.
Uyu murwayi, wasuzumwe indwara ya myeloma nyinshi yasubiwemo/yasubiwemo, ubwoko bwa IgA-λ (R-ISS Stage II), yari yarigeze kugirwa imiti ivanze itatu hamwe no guterwa uturemangingo tw’amaraso mu maraso. Nyuma y’uko indwara ikomeje nyuma y’ubuvuzi buheruka, umurwayi yinjiye mu igerageza rya muganga. Nyuma yo guterwa uturemangingo twa CAR T ku gipimo cyo hasi cyane hakurikijwe amabwiriza y’ubuvuzi, umurwayi yagize ikibazo cyo kurekura cytokine cytokine (CRS) cyo mu cyiciro cya mbere, cyavuwe neza hakoreshejwe imiti igabanya ubukana na tocilizumab, kandi umurwayi ntiyagaragaje indwara y’ubudahangarwa bw’umubiri (ICANS) cyangwa izindi ndwara zifitanye isano na CAR-T, bigaragaza ko afite umutekano mwiza muri rusange.
Ubu buvuzi bwa CAR-T bwateguwe kugira ngo buvure indwara ya myeloma nyinshi yasubiwemo/irwara indwara ya refractory multiple myeloma (R/R MM) na leukemia y’uturemangingo twa plasma yasubiwemo/irwara refractory (R/R PCL). Amakuru y’inyongera ateganijwe mu gice cya kabiri cy’uyu mwaka.
Kugeza ubu, haracyari igeragezwa ryinshi ry’ikoranabuhanga rishya rirwanya kanseri mu Bushinwa rishaka abarwayi. Inama ku miti mishya n’ikoranabuhanga, ushobora kuvugana n’Ishami Mpuzamahanga ry’Ibitaro bya Oncology bya Beijing mu Karere k’Amajyepfo.
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Amareferensi
2.https://www.prnasia.com/
Igihe cyo kohereza: Gashyantare-11-2025