Ku ya 10 Werurwe 2026, umuti ugezweho wa B7-H3-targeting antibody-drug conjugate (ADC) YL201 wo guterwa inshinge, wakozwe na MediLink Therapeutics, wemerewe Breakthrough Therapy na Ikigo gishinzwe gusuzuma imiti mu Bushinwa gishinzwe ibicuruzwa by’ubuvuzi. Iki kimenyetso cyagenwe kiri kumwe na Serplulimab mu kuvura kanseri y’ibihaha mu cyiciro cya mbere (ES-SCLC).
YL201 ni ADC nshya yibasira cyane B7H3. Poroteyine ya B7H3 igaragara cyane ku tunyangingo twa kanseri n'utunyangingo dutangiza kanseri tw'ubwoko butandukanye bw'ibibyimba ariko ifite ubushobozi buke mu mikorere isanzwe, bigaragaza ko ishobora kuba umuti wibasira ADC. YL201 yakozwe hakoreshejwe ikoranabuhanga rya MediLink rya Tumor Microenvironment Activable LINKer-payload (TMALIN®) rihujwe na antibody ya B7H3 yihariye. Kuri ubu, YL201 irimo gukorwaho ubushakashatsi ku tunyangingo dutandukanye tw’ibibyimba bikomeye kandi yinjiye mu igeragezwa rikomeye muri Kanseri y’ibihaha y’uturemangingo duto na Kanseri yo mu mazuru mu Bushinwa.
### Amakuru y'ubuvuzi yemewe: Imikorere myiza n'umutekano mwiza
Muri Werurwe 2025, ikinyamakuru mpuzamahanga cy’urwego rwo hejuru *Nature Medicine* cyasohoye amakuru yavuye mu igerageza rya YL201 rya Phase 1/1b ku barwayi bafite ibibyimba bikomeye. Ubu bushakashatsi, bugizwe n’abarwayi 312, bwagaragaje:
- **Imikorere Muri Rusange:** Mu barwayi 287 bapimwe, igipimo cy’ubutabazi bw’ibanze (ORR) cyari gitangaje kuri 40.8%, harimo abarwayi 2 basubije neza (CR) na 115 basubije igice (PR). Igipimo cyo kurwanya indwara (DCR) cyageze kuri 83.6%.
- **Kanseri y'ibihaha y'uturemangingo duto twibasiwe cyane (ES-SCLC):** Ku barwayi bavuwe mbere hakoreshejwe imiti ishingiye kuri platine, ORR yari 63.9%, DCR yari 91.7%, naho ubuvuzi bw'ibanze budafite progression (mPFS) bwari amezi 6.3.
- **Kansinoma yo mu mazuru (NPC):** Mu barwayi 70, ORR yari 48.6%, DCR yari 92.9%, abarwayi 2 bakira neza. Igihe mpuzandengo cy'igihe cyo gusubiza (mDOR) cyari amezi 8.4.
Aya makuru yemeza neza imikorere ikomeye yo kurwanya ikibyimba n'umutekano wa YL201 mu bwoko butandukanye bw'ibibyimba bikomeye, bishyiraho urufatiro rukomeye rw'ubushakashatsi bukurikiraho mu buvuzi no mu buryo bwagutse.
### Ishami Mpuzamahanga ry'Ibitaro bya Oncology byo mu Karere k'Amajyepfo ka Beijing: Ikiraro cyawe cy'Ubuvuzi Mpuzamahanga
Ishami Mpuzamahanga ry’Ibitaro bya Oncology byo mu Karere k’Amajyepfo rya Beijing rihora ryiyemeje gutangiza ikoranabuhanga rikomeye ku isi ryo gusuzuma no kuvura kanseri ndetse n’imiti. Dukurikiranira hafi iterambere ry’ubushakashatsi bugezweho kandi dukomeza ubufatanye bukomeye n’ibigo bikomeye bya siyansi haba mu gihugu no mu mahanga, duharanira guha abarwayi mpuzamahanga uburyo bwo kuvura ku gihe harimo na YL201.
Itsinda ryacu Mpuzamahanga rishinzwe abarwayi rishobora kuguha ibi bikurikira:
- **Isuzumabumenyi ryihariye ry’ubuvuzi:** Itsinda ry’abaganga b’ingeri nyinshi (MDT) rizasuzuma neza inyandiko zawe z’ubuvuzi kugira ngo rimenye niba uburyo bwo kuvura bwa ADC bukwiriye indwara yawe.
- **Kubona ubuvuzi mu buryo bworoshye:** Gufashwa kubona viza zo kujya mu Bushinwa, gutegura gahunda y'inama z'inzobere, gutegura serivisi zo gusobanura, no guhuza uburyo bwo kwinjira mu bitaro kugira ngo umuntu agire uburambe buzira umuze.
### Twandikire ubu kugira ngo ubone amakuru arambuye
Niba wowe cyangwa uwo ukunda muhanganye n'ibibazo bijyanye na kanseri y'ibihaha ifite uturemangingo duto, kanseri yo mu mazuru, cyangwa izindi kanseri zikomeye, kandi mukaba mwifuza kumenya byinshi ku buvuzi bugezweho bwa ADC cyangwa gusuzuma amahirwe yo kuvurwa, nyamuneka hamagara Ishami Mpuzamahanga ry'Ibitaro bya Oncology bya Beijing mu Karere k'Amajyepfo byihuse. Inzobere zacu mpuzamahanga mu bijyanye n'abarwayi zizasubiza ikibazo cyawe mu masaha 24.
**Amakuru yo guhamagara:**
- **Terefone:** 400-880-3716���
- **WeChat:** 17801183037
- **Imeri:**
100085_010@163.com
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Turumva ko inzira yo kuvura kanseri igoye, ariko buri kintu cyose gishya kigaragaza icyizere gishya. Ishami Mpuzamahanga ry’Ibitaro Mpuzamahanga bya Oncology bya Beijing mu Karere k’Amajyepfo ryifuza gufashwa namwe, rikoresheje ikoranabuhanga ry’inzobere mu buvuzi n’ubuvuzi bushyushye kandi bw’impuhwe, kugira ngo dufatanye gutsinda kanseri no kwakira ubuzima bw’abantu.
Igihe cyo kohereza ubutumwa: Werurwe-24-2026